• Pinboard Links

    Flap’s Links and Comments for June 3rd on 12:54

    These are my links for June 3rd from 12:54 to 15:02:

  • Bisphosphonates,  Dentistry

    Oral Hygiene and Antibiotics Play a Role in Healing and Pain Alleviation in Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ)


    Osteonecrosis of the jaw in a patient who had poor oral hygiene and generalized periodontal disease and recently underwent routine dental extractions in the mandible. This patient had undergone monthly intravenous bisphosphonate therapy for treatment of multiple myeloma during the previous 12 months.
    Photo credit: Mayo Clinic

    According to this new paper here.

    Abstract

    OBJECTIVES:

    The objectives of this study were to define the incidence, pain, and healing in cancer patients treated with intravenous bisphosphonates.

    STUDY DESIGN:

    The study included long-term follow-up of 99 bisphosphonate-using patients (group A) and conservative treatment of 67 patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ, group B) using 3 antibiotic schemes and oral hygiene.

    RESULTS:

    The frequency of zoledronic acid single-agent use was 85.9% and 69.8% in group A and B, respectively. Median follow-up was 13 months (group A) and 16 months (group B). Two patients in group A developed BRONJ (2%). Of those with BRONJ in group B who completed follow-up, healing occurred in 14.9% (7/47) and pain subsided in 80.9% (38/47). Healing was significant in patients who received pamidronate followed by zoledronic acid (P = .023) and with BRONJ stages 0 and stage I (P = .003).

    CONCLUSIONS:

    This case series suggests that oral hygiene and conservative antibiotic therapy play a role in healing and pain alleviation in BRONJ. Oral hygiene and follow-up may decrease incidence of BRONJ.

    This sounds a reasonable course, knowing that this complication will be found to occur with increasing frequency. Let us hope a conservative protocol can be developed for these unfortunate patients.

    Previous:

    Jury Finds Novartis the Manufacturers of Zometa Not Liable for Osteonecrosis of the Jaw

    Osteonecrosis
    of the Jaw Associated With Bisphosphonate Agent Zoledronic Acid and
    Chemotherapy Combined With the Antiangiogenic Agent Bevacizumab

    Oral Bisphosphonates: Study – Absolute Risk for Femur Fracture Low with Bisphosphonates

    Revisiting Bisphosphonates and Femur Fractures

    Oral Bisphosphonates Associated with a SLIGHTLY Elevated Risk of Developing Osteonecrosis of the Jaw?

    New Dentistry Cause for Alarm for Patients Who Use Bisphosphonates – Fosamax, Actonel, Boniva?

    Dentistry Today: Bisphosphonates: Zometa (zoledronic acid) & Aredia (pamidronate disodium) Associated with Osteonecrosis of Jaw – REDUX

    Bisphosphonates: Zometa (zoledronic acid) & Aredia (pamidronate dis odium) Associated with Osteonecrosis of Jaw

  • Pinboard Links

    Flap’s Links and Comments for June 3rd on 12:32

    These are my links for June 3rd from 12:32 to 12:50:

    • Proposed political district maps would sever most of Thousand Oaks from county – Most of Thousand Oaks would be politically detached from the rest of Ventura County under staff proposals presented Thursday to the Citizens Redistricting Commission.

      The proposals, the first maps to emerge from the commission, were presented as the panel prepares to release its full set of draft legislative and congressional districts next week.

      Under these first-draft ideas, the commission's line-drawers suggest Thousand Oaks be split in Assembly, Senate and congressional districts, with most of the city being grouped with portions of Los Angeles County.

      Perhaps most significant was the line-drawers' proposal to place about three-quarters of Thousand Oaks' population in an L.A. County-centered congressional district. If that recommendation were to be adopted, it would create a Ventura County-only district to the west that retains Simi Valley, the home and political base of incumbent Republican Rep. Elton Gallegly, who has represented most of the county for more than two decades.

      Earlier this week, commissioners suggested that most of Simi Valley —– rather than Thousand Oaks — be detached in order to meet the population requirements for a district that would contain nearly all the remainder of the county.

    • Obama’s Economic Debacle – Major news outlets are suddenly all agog because the vaunted Obama economic recovery not only never was much of a recovery at all, but also seems to be disappearing. “We are on the verge of a great Great Depression!” screams Drudge’s massive headline in red. The Wall Street Journal reports the bad news that the private-sector economy added only 38,000 jobs last month. The Washington Post announces that “U.S. economic recovery is faltering.” CNBC says Wall Street is “baffled.”

      The only thing that should be baffling is why anybody at all is surprised.

      This is what happens when government becomes too big, too intrusive, too debt-ridden and too unpredictable. Almost every root of the current economic distress – the longest post-WWII recession on record – stretches down to rotten government policy. The reasoned compassion of Jack Kemp’s promotion of home ownership was shifted by the Clinton Administration into forced lending practices. Fannie Mae and Freddie Mac, while paying exorbitant salaries and bonuses to Clinton cronies, ran amuck. Lending standards were eviscerated at government’s behest.

    • Greenspan ‘Scared’ Over Deficit; Calls for Debt Ceiling Rise – The debt and deficit problem in the US is so serious that former Federal Reserve Chairman Alan Greenspan finds himself in the position of recommending the highest tax rates in more than a decade.

      In an interview with CNBC, the former central bank chief described himself as a "small government, free-market economist" who nonetheless believes that in order to raise revenue and close the debt gap, 1990s-era taxes must be reinstituted.

      It's a measure, he said, of how serious the problem has become.

      "The fact that I am in favor of going back to the Clinton tax structure is merely an indicator of how scared I am of this debt problem that has emerged and its order of magnitude," he said.

    • Economic Recovery Is Languishing as Americans Await Signal of Better Times – In 1901, William Randolph Hearst’s New York Journal launched a cartoon featuring two overly polite friends named Alphonse and Gaston. Each insisted with conspicuous courtesy that the other go first. Amid elaborate bowing, scraping, and apres-vous-ing, Alphonse and Gaston never managed to make it through an open doorway.

      Now, 110 years later, economists have a name for the Alphonse and Gaston routine that’s hobbling the U.S. economy: “coordination failure,” Bloomberg Businessweek reports in its June 6 edition. Companies won’t hire because customers won’t spend. Customers won’t spend because companies won’t hire. This stare-down has been going on since approximately December 2007, when the worst slump since the Great Depression took hold. Many Americans would like someone to make a move so they can get back to prosperity. Yet they’ve lost confidence in the actions that were designed to build confidence and restore growth –namely, near-zero overnight interest rates, the bailout of the financial system, a weakening dollar, and stimulus measures that add to the federal budget deficit and the national debt.

    • When Will Economy Recover? 2014, If Ever, Survey Says – Americans are growing increasingly doubtful about direction of the US economy, according to the latest survey from business-advisory firm AlixPartners.

      In fact, an increasing number, some 61 percent, say they don't expect to return to their respective pre-recession lifestyles until the spring of 2014, if ever.

      What's worse, a full 10 percent said they expect they will never return to pre-recession spending.

      That's a more pessimistic view than last year, when those surveyed expected that they could be back to pre-recession spending levels by the middle of 2013.

      "Americans continue to push their expectations for return to a pre-recession 'normal' further and further into the future—close enough for comfort, but far enough away to seem realistic," said Fred Crawford, CEO of AlixPartners. "But as that happens, more and more it seems normal is actually where we are right now."

      ======

      Not until Obama is gone….

    • Obamanomics in a Nutshell – The Auto Bailouts – It's a sign of grim times indeed when the Obama administration is touting a potential $14 billion loss to the taxpayers as a great economic success.

      The White House is running on its auto bailouts as courageous acts that saved the industrial Midwest. To critics of government intervention, the administration holds up the revival of General Motors and Chrysler as proof of the efficacy – nay, the necessity – of bailout economics.

      It's a telling point of pride. In bragging about the bailouts, the administration is boasting of a process shot through with lawlessness and political favoritism, not to mention reckless disregard for taxpayer dollars. Few acts have so powerfully captured Pres. Barack Obama's corporatism.

      The administration believes it trumps all criticism with one data point: GM and Chrysler are still with us. GM has even been making money, and had the biggest IPO in American history last November.

      Yet, as Megan McArdle of The Atlantic tartly observes, it shouldn't have been in doubt that if government threw $80 billion at two companies, not expecting to get all of it back, it could save them. She points out that the loss from the bailouts (the administration's estimate is $14 billion) will be close to the entire market capitalization of GM in 2007. It will be several times as big as the company's 2008 market capitalization.

      McArdle figures that, at a cost of roughly $10 billion to $20 billion, we might as well have given GM's pre-bankruptcy workforce of 75,000 hourly workers $250,000 each and called it a day.

      ======

      Read it all

  • Pinboard Links

    Flap’s Links and Comments for June 3rd on 12:32

    These are my links for June 3rd from 12:32 to 12:50:

    • Proposed political district maps would sever most of Thousand Oaks from county – Most of Thousand Oaks would be politically detached from the rest of Ventura County under staff proposals presented Thursday to the Citizens Redistricting Commission.

      The proposals, the first maps to emerge from the commission, were presented as the panel prepares to release its full set of draft legislative and congressional districts next week.

      Under these first-draft ideas, the commission's line-drawers suggest Thousand Oaks be split in Assembly, Senate and congressional districts, with most of the city being grouped with portions of Los Angeles County.

      Perhaps most significant was the line-drawers' proposal to place about three-quarters of Thousand Oaks' population in an L.A. County-centered congressional district. If that recommendation were to be adopted, it would create a Ventura County-only district to the west that retains Simi Valley, the home and political base of incumbent Republican Rep. Elton Gallegly, who has represented most of the county for more than two decades.

      Earlier this week, commissioners suggested that most of Simi Valley —– rather than Thousand Oaks — be detached in order to meet the population requirements for a district that would contain nearly all the remainder of the county.

    • Obama’s Economic Debacle – Major news outlets are suddenly all agog because the vaunted Obama economic recovery not only never was much of a recovery at all, but also seems to be disappearing. “We are on the verge of a great Great Depression!” screams Drudge’s massive headline in red. The Wall Street Journal reports the bad news that the private-sector economy added only 38,000 jobs last month. The Washington Post announces that “U.S. economic recovery is faltering.” CNBC says Wall Street is “baffled.”

      The only thing that should be baffling is why anybody at all is surprised.

      This is what happens when government becomes too big, too intrusive, too debt-ridden and too unpredictable. Almost every root of the current economic distress – the longest post-WWII recession on record – stretches down to rotten government policy. The reasoned compassion of Jack Kemp’s promotion of home ownership was shifted by the Clinton Administration into forced lending practices. Fannie Mae and Freddie Mac, while paying exorbitant salaries and bonuses to Clinton cronies, ran amuck. Lending standards were eviscerated at government’s behest.

    • Greenspan ‘Scared’ Over Deficit; Calls for Debt Ceiling Rise – The debt and deficit problem in the US is so serious that former Federal Reserve Chairman Alan Greenspan finds himself in the position of recommending the highest tax rates in more than a decade.

      In an interview with CNBC, the former central bank chief described himself as a "small government, free-market economist" who nonetheless believes that in order to raise revenue and close the debt gap, 1990s-era taxes must be reinstituted.

      It's a measure, he said, of how serious the problem has become.

      "The fact that I am in favor of going back to the Clinton tax structure is merely an indicator of how scared I am of this debt problem that has emerged and its order of magnitude," he said.

    • Economic Recovery Is Languishing as Americans Await Signal of Better Times – In 1901, William Randolph Hearst’s New York Journal launched a cartoon featuring two overly polite friends named Alphonse and Gaston. Each insisted with conspicuous courtesy that the other go first. Amid elaborate bowing, scraping, and apres-vous-ing, Alphonse and Gaston never managed to make it through an open doorway.

      Now, 110 years later, economists have a name for the Alphonse and Gaston routine that’s hobbling the U.S. economy: “coordination failure,” Bloomberg Businessweek reports in its June 6 edition. Companies won’t hire because customers won’t spend. Customers won’t spend because companies won’t hire. This stare-down has been going on since approximately December 2007, when the worst slump since the Great Depression took hold. Many Americans would like someone to make a move so they can get back to prosperity. Yet they’ve lost confidence in the actions that were designed to build confidence and restore growth –namely, near-zero overnight interest rates, the bailout of the financial system, a weakening dollar, and stimulus measures that add to the federal budget deficit and the national debt.

    • When Will Economy Recover? 2014, If Ever, Survey Says – Americans are growing increasingly doubtful about direction of the US economy, according to the latest survey from business-advisory firm AlixPartners.

      In fact, an increasing number, some 61 percent, say they don't expect to return to their respective pre-recession lifestyles until the spring of 2014, if ever.

      What's worse, a full 10 percent said they expect they will never return to pre-recession spending.

      That's a more pessimistic view than last year, when those surveyed expected that they could be back to pre-recession spending levels by the middle of 2013.

      "Americans continue to push their expectations for return to a pre-recession 'normal' further and further into the future—close enough for comfort, but far enough away to seem realistic," said Fred Crawford, CEO of AlixPartners. "But as that happens, more and more it seems normal is actually where we are right now."

      ======

      Not until Obama is gone….

    • Obamanomics in a Nutshell – The Auto Bailouts – It's a sign of grim times indeed when the Obama administration is touting a potential $14 billion loss to the taxpayers as a great economic success.

      The White House is running on its auto bailouts as courageous acts that saved the industrial Midwest. To critics of government intervention, the administration holds up the revival of General Motors and Chrysler as proof of the efficacy – nay, the necessity – of bailout economics.

      It's a telling point of pride. In bragging about the bailouts, the administration is boasting of a process shot through with lawlessness and political favoritism, not to mention reckless disregard for taxpayer dollars. Few acts have so powerfully captured Pres. Barack Obama's corporatism.

      The administration believes it trumps all criticism with one data point: GM and Chrysler are still with us. GM has even been making money, and had the biggest IPO in American history last November.

      Yet, as Megan McArdle of The Atlantic tartly observes, it shouldn't have been in doubt that if government threw $80 billion at two companies, not expecting to get all of it back, it could save them. She points out that the loss from the bailouts (the administration's estimate is $14 billion) will be close to the entire market capitalization of GM in 2007. It will be several times as big as the company's 2008 market capitalization.

      McArdle figures that, at a cost of roughly $10 billion to $20 billion, we might as well have given GM's pre-bankruptcy workforce of 75,000 hourly workers $250,000 each and called it a day.

      ======

      Read it all

  • Polling,  President 2012,  Sarah Palin

    President 2012 GOP Poll Watch: Sarah Palin’s Poll Numbers By State

    Former Alaska Gov. Sarah Palin, left, poses with celebrity look-alike impersonator Cecilia Thompson during a tour of Boston’s North End neighborhood, Thursday, June 2, 2011. Palin’s father Chuck Heath is at center

    Rush Limbaugh and Mark Levin can defend Sarah Palin from Charles Krauthammer and others all they want. But, what they cannot argue are Palin’s, thus far, very poor poll numbers.

    The summary:

    • 12 of the states where we’ve polled on Palin went for John McCain in 2008. Her average favorability in those GOP friendly states is 38/54
    • 8 of the states where we’ve polled are ones that George W. Bush won in 2004 and Barack Obama won in 2008- obviously the ones that will be most important to Republican prospects of taking back the White House. Her average favorability in those vital swing states is 32/61
    • There’s been a lot of recent buzz that Palin is moving to Arizona. She will be getting away from a state where she is unpopular (33/58 favorability in Alaska), but she is moving to one where she’s even more unpopular (32/62 favorability in Arizona.)

    Here is the graph:

    Ok, so what does this mean?

    You might say, well, the PPP Polling organization is a Democratic polling firm and that they are biased.

    Fair enough!

    You could say this, but biased polling in 31 states which are corroborated in part by polling by other polling organizations?

    This is not to say that Sarah Palin cannot win the GOP nomination.

    But, she reads the polls, like Krauthammer and they know she faces a very strong current of opinion to swim against in order to beat President Obama.

    Wouldn’t it be far better to support a GOP Presidential candidate that can win in 2012, accept a cabinet appointment, e.g. Energy or Interior, then run for the Presidency another year, after some political rehabilitation?

  • President 2012,  Rudy Giuliani,  Sarah Palin

    President 2012: Rudy Giuliani Sets Late Summer Decision – Waiting for Sarah Palin?

    Former NYC mayor Rudy Giuliani, right, poses after autographing a sign for David Peterson at a Republican luncheon, Thursday, June 2, 2011, at Vito Marcello’s Italian Bistro in North Conway, N.H.

    Former New York City Mayor Rudy Giuliani will make a definitive decision on a Presidential run by late summer.

    After spending the day in New Hampshire, Rudy Giuliani says he has settled on a timeframe for making up his mind about entering the 2012 race.

    Late summer “seems like a natural period of time,” the former New York City mayor said in an interview with POLITICO from New Hampshire. “I think during the summer people don’t pay as much attention.”

    “I have the advantage of very high name-recognition,” he added, explaining his decision to wait.

    Waiting until Labor Day would also Giuliani time to see how the field shakes out, including the effect from the heavily-watched Ames Straw Poll in Iowa, generally seen as the first major test of organizational strength.

    Again, there has been NO Bat Signal from Gotham as of yet for former Rudy supporters to get ready. But, I am positive that Rudy will throw his hat in the ring if Sarah Palin runs.

    Sarah Palin will throw the race upside down and with Mitt Romney wounded over “RomneyCare,” who can the GOP Establishment support?

    Giuliani has a track record of decades of accomplishment and excellent name identification. He can beat Romney and Palin in East and West Coast GOP primary elections. He can win Florida.

    However, he will struggle in Iowa and South Carolina, but let Palin and Bachmann duel it out there. Romney won’t do well there either.

    So, what is a convenient starting point for Rudy? New Hampshire, of course. If Rudy can run second to Romney, but close – he has a shot.

    In the general election, Giuliani would be formidable against President Obama in the key battleground states of Ohio, Florida, Nevada and New Hampshire.

    Watch Sarah Palin, if she runs, then so does Rudy.

  • John Edwards,  Rielle Hunter

    Video: John Edwards Indicted and Arrest Warrant Issued

    If you think politics and politicians are bad, it only get worse with the John Edward’s story. Watch the video above for a complete and sordid timeline of the John Edward’s affair with Rielle Hunter.

    A federal grand jury indicted former North Carolina senator and presidential candidate John Edwards Friday.

    Sources tell ABC11 that Edwards will make his first court appearance at 1:30 p.m. in Winston-Salem.

    The case of United States of America v. Johnny Reid Edwards contains six counts, including conspiracy, four counts of illegal campaign contributions and one count of false statements. A warrant for his arrest has been issued.

    The federal indictment can be found here.

    The indictment says he “did knowingly and willfully combine, conspire, confederate, and agree with others” to “accept and receive, while a candidate for federal office, contributions” “in excess of the limits of the Elections Act.”

    The indictment says Edwards’ actions caused his campaign to file false campaign finance reports. It goes on to say the purpose of the conspiracy was to cover up the former senator’s affair with Rielle Hunter.

    I covered this story many years ago and it was very obvious that Edwards was lying and covering up his affair with Rielle Hunter in order to save his political hide. He will have to plead guilty to a federal felony in order to avoid federal prison and be disbarred.

    Wonder if Ms. Hunter will want him now?

  • Herman Cain,  Mitt Romney,  Newt Gingrich,  Polling,  President 2012,  Sarah Palin,  Tim Pawlenty

    President 2012 Iowa Poll Watch: Obama 49% Vs. Romney 40%, Obama 55% Vs. Palin 35%

    Electoral College vote map of Larry Sabato

    According to the latest PPP Poll.

    Job Approval Vs. Disapproval:

    • President Barack Obama – 49% Vs. 46%

    Favorable Vs. Unfavorable:

    • Newt Gingrich – 19% vs. 63%
    • Sarah Palin – 29% Vs. 63%
    • Mitt Romney – 35% Vs. 47%
    • Tim Pawlenty – 25% Vs. 41%
    • Herman Cain – 20% vs. 40%

    General Election Head to Head:

    • Obama – 54% Vs. Gingrich – 33%
    • Obama – 55% Vs. Palin – 35%
    • Obama – 49% Vs. Romney – 40%
    • Obama – 49% Vs. Pawlenty – 37%
    • Obama – 50% Vs. Cain – 32%

    Although President Obama is doing better in Iowa than the past polling period, his job approval ratings still lag. Obviously, Iowa voters are not happy with the current GOP Presidential field and they all perform less than John McCain in 2008.

    When PPP polled Iowa in mid-April Barack Obama had negative approval numbers, was tied with Mike Huckabee, and led Mitt Romney by only 4 points in a state that he won by 10 points against John McCain in 2008. Now six weeks later Obama’s fortunes in the state have shifted dramatically, symbolizing the uptick in his political fortunes we’ve seen throughout the country in the month since the killing of Osama bin Laden. He now has positive approval numbers, doesn’t have to worry about Huckabee anymore, and has built his lead over Romney to a 9 point margin similar to what he won the last time around.

    Also, Iowa is NOT considered by many to be a KEY battleground state that the GOP will need to beat Obama in the Electoral College. See the list here.

    Obama’s approval numbers in Iowa aren’t that strong and it would certainly be premature to declare 17 months out from the election that he’ll win the state again. But the numbers here are another reminder that the weak Republican field is his greatest ally as he moves toward reelection, and that the GOP will have to come up with a stronger candidate to have a serious chance of defeating Obama next year.

    The entire poll is here.

  • California,  Circumcision,  Flap's California Morning Collection

    Flap’s California Morning Collection: June 3, 2011

    A morning collection of links and comments about my home, California.

    Literature for SF’s anti-circumcision measure stars “monster” rabbis and blonde superheroes

    San Francisco’s anti-circumcision measure will be decided by voters in November, but the literature for the moovement aims to sway them with some disturbing images — including dark, evil-looking rabbis and a blonde superhero saving babies from their clutches.

    The measure, supported by self-described “inactivists,” would make circumcision performed on anyone under 18 a misdemeanor, even if it is done for religious purposes.

    It would be punishable by a $1000 fine, or up to a year in jail.

    California Citizens Redistricting Commission – First Batch of Legislative District Maps due for release next Friday

    These “visualizations” are starting points based only on public testimony so far.

    Circumcision and the Special City

    In 2010 San Francisco supervisors banned Happy Meals. They showed no regard for parental choice.

    So it should not come as a shock that activists have managed to put a measure on the November ballot that essentially would outlaw the circumcision of baby boys. If it passes, then parents won’t be able to choose to circumcise their infant sons. The penalty for the “genital cutting of male minors” will be a $1,000 fine and/or up to a year in jail.

    The ballot measure bills itself as a ban on “forced genital cutting” and “mutilation.” Clearly the authors want to confuse voters by equating male circumcision to female genital mutilation, the barbaric, unsanitary butchering of a young girl’s private parts in a procedure that has been known to leave girls severely infected and in pain.

    The purpose of female genital mutilation is to reduce a woman’s sexual pleasure. The World Health Organization says it has “no health benefits for girls or women.” On the other hand, a 2007 WHO report recommended that male circumcision be recognized as “an efficacious intervention for HIV prevention.”

    The American Academy of Pediatrics suggests that parents be informed that “newborn male circumcision has potential medical benefits and advantages as well as disadvantages and risks.” Palo Alto pediatrician Erica Goldman follows the guideline. She informs parents of the pluses – reduced chances of urinary tract infection and sexually transmitted diseases – as well as the risks – it’s a permanent cosmetic change. “It really is a decision to be made on a personal and cultural basis,” Goldman told me.

    “I personally believe the medical benefits outweigh the medical risks,” Goldman added.

    Online social network privacy bill dies in Senate

    A bill designed to give online social network users more control about how their personal information is displayed on websites failed to muster enough votes to pass the Senate today.

    The California Chamber of Commerce and many companies in the Internet technology industry had said the bill would stifle innovation in one California’s growing industries.

    The measure’s author, Sen. Ellen Corbett, D-San Leandro, said it made “all the sense in the world” to let users opt-in to reveal anything more than their name and city of residence. The measure would have forced users to set their privacy settings as part of the registration process to join sites such as Facebook, Twitter, LinkedIn, Eharmony and Match.com.

    Enjoy your morning!

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    Flap’s California Collection Archive